Natural variation in non-coding regions underlying phenotypic diversity in budding yeast
نویسندگان
چکیده
منابع مشابه
Natural variation in non-coding regions underlying phenotypic diversity in budding yeast.
Linkage mapping studies in model organisms have typically focused their efforts in polymorphisms within coding regions, ignoring those within regulatory regions that may contribute to gene expression variation. In this context, differences in transcript abundance are frequently proposed as a source of phenotypic diversity between individuals, however, until now, little molecular evidence has be...
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Non-coding transcripts play an important role in gene expression regulation in all species, including budding and fission yeast. Such regulatory transcripts include intergenic ncRNA (non-coding RNA), 5' and 3' UTRs, introns and antisense transcripts. In the present review, we discuss advantages and limitations of recently developed sequencing techniques, such as ESTs, DNA microarrays, RNA-Seq (...
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Our current understanding of how natural genetic variation affects gene expression beyond well-annotated coding genes is still limited. The use of deep sequencing technologies for the study of expression quantitative trait loci (eQTLs) has the potential to close this gap. Here, we generated the first recombinant strain library for fission yeast and conducted an RNA-seq-based QTL study of the co...
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The microbe humans love best is yeast. For thousands of years it has provided our favourite drug, alcohol, and in return we have fed and housed it. Most of our long love affair has been conducted in the dark, but in 1875 a Danish brewer founded the Carlsberg Laboratory to apply science to the brewing industry, and since then we have pored over the inner workings of Saccharomyces in a frenzy of ...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2016
ISSN: 2045-2322
DOI: 10.1038/srep21849